Hip osteoarthritis increases stroke risk.

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Hip osteoarthritis increases stroke risk.

According to a study, hip osteoarthritis may raise the incidence of stroke, ischemic stroke, and small-vessel ischemic stroke.

Yingjun Li, MD, of the School of Public Health at Hangzhou Medical College, in Hangzhou, China, and co-authors wrote, "the real causal relationship between OA and stroke remains unclear because conclusions derived from observational studies were potentially biassed due to residual confounding such as OA medications and reverse causality." Using a novel Mendelian randomization (MR) method, the authors "confirmed whether OA is causally connected with stroke" and "investigated whether the stroke is causally associated with OA."

According to research published in 2022 by Zhao et al. in Osteoarthr Cartil. (doi:10.1016/j.joca.2022.06.006), OA in the hip may increase the risk of ischemic, non-fatal, and small-vessel ischemic stroke.

Li and colleagues conducted a bidirectional two-sample Mendelian randomization trial. They analyzed public data from large-scale genome-wide association studies to discover whether or not OA of the hip was associated with an increased risk of stroke.

The researchers used Arthritis Research UK's Osteoarthritis Genetics and the UK Biobank to collect data on the geographic distribution of OA. A total of 40,585 stroke patients and 406,111 control patients were included in the meta-analysis of 29 genome-wide association studies. When working with a single nucleotide polymorphism, the authors applied an inverse-variance weighting (IVW) technique based on bidirectional Mendelian randomization.

Because of a shortage of information, the authors could not explore the possible correlation between intracerebral haemorrhages and OA.

Stroke in general (IVW OR = 1.12; 95% CI, 1.06-1.20), ischemic stroke (OR = 1.13; 95% CI, 1.06-1.21), and small-vessel ischemic stroke (OR = 1.25; 95% CI, 1.10-1.42) were all substantially related with a higher risk for hip OA, as shown by the researchers. The authors said the analysis did not find any association between stroke risk and osteoarthritis risk.

This is the first two-sample MR study to understand the bidirectional causal link between osteoarthritis and stroke (40,585 cases and 406,111 controls from the MEGASTROKE project). As a result of our two-sample MR study, we conclude a causal relationship between hip OA and stroke and stroke subtypes.

Further research is needed to understand the causal linkages between OA and stroke.

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